吴双教授，博士生导师

吴双福建农林大学园艺学院/未来技术学院园艺中心教授，目前为园艺一级学科带头人，国家良种联合攻关青梗菜项目首席专家。主要研究领域为蔬菜生长发育调控与环境适应。在Science、Dev Cell、Nature Communications、PNAS、Plant Cell 等国际刊物发表论文70余篇，并获批4项专利。曾先后获得中组部千人计划青年项目（2015），基金委优秀青年基金（2017），福建省百人计划等。并先后获得2016年福建省青年科技奖、2018年严家显最高奖教金、2023年福建省优秀教师等荣誉。先后主持多项国家重点研发项目子课题，基金委面上项目，福建省重大专项等课题。担任国际著名学术期刊Plant Cell编委，以及Current Biology咨询专家委员，并担任包括Frontiers in Plant Sci，Vegetable Research，New Crops等多个学术期刊的编委。曾应邀为欧盟研究委员会、香港研究基金委员会等评审项目基金，也长期担任 Nature Plants、PNAS、Mol Plant、Plant Cell 等杂志审稿专家。联系方式: Email: [email protected]英文主页：-ucr-hbmc.ucr.edu/shuang.html学习及工作经历：2015-     福建农林大学海峡联合研究院，教授2009-2014 美国宾夕法尼亚大学，博士后2003-2009 美国麻省大学，植物生物学，博士研究兴趣:（1）植物干细胞维持、分裂和分化的分子生物学基础（2）植物表皮结构特化与环境适应的系统生物学研究（3）植物根系营养吸收与逆境适应的细胞分子生物学机制（4）番茄，青梗菜等蔬菜生长发育调控和品质优化的分子基础研究方向：不同于动物，植物不能逃避逆境。因此植物进化出对环境适应巨大的可塑性。这种可塑性部分是通过不断得形成新的器官而实现。器官发生是生命科学的核心问题之一，从一个简单的细胞形成具有复杂结构的器官需要在时间和空间上进行精确的调控。这个调控依赖于两个过程: 细胞分裂和细胞命运的决定。我们组的研究围绕这两个问题，在多个层面上进行了展开。我们希望理解植物干细胞在特定位置上为什么具有准确分裂方向的调整，从而产生不同的细胞层来构建器官。我们也想知道不同位置上的细胞命运是如何决定的。与动物不同，植物里通常认为位置信息决定了细胞类型的确立，而位置信息的本质是什么长久以来一直不清楚。我们实验室的切入点是从细胞间信号交流的角度去探索植物器官发育中相邻细胞是如何通过“交谈”而实现各自命运的决定。在这个分子和细胞机制的基础上，我们进一步想探明植物根系是如何接收到环境的信号，通过一系列的信号传递，对自身的发育过程进行调控，从而更好的去吸收水分养分，适应不同环境条件。发表论文:1. Wu M, Bian X, Huang B, Du Y, Sheng J, Hu S, Wang Y, Wu S.* (2024) HD-Zip proteins modify floral structures for self-pollination in tomato. Science DOI:10.1126/science.adl19822. Chang J, Wu S, You T, Wang J, Sun B, Xu B, Xu X, Zhang Y, Wu S.* (2024) Spatiotemporal formation of glands in plants is modulated by MYB-like transcription factors. Nature Communications in press3. Wu M, Bian X, Hu S, Huang B, Du Y, Sheng J, Wang Y, Xu M, Xu H, Yang M, Wu S.* (2024) A gradient of the HD-Zip regulator Woolly regulates multicellular trichome morphogenesis in tomato. The Plant Cell in press4. Wu J, Li P, Li M, Wu S.* (2024) SlCRCa is a key D class gene controlling ovule fate determination in tomato. Plant Biotechnology Journal in press5. Wu J, Li P, Li M, Zhu D, Ma H, Xu H, Li, S, Wei J, Wu S.* (2024) Heat stress impairs floral meristem termination and fruit development via affecting BR-SlCRCa cascade in tomato. Plant Communications DOI: 10.1016/j.xplc.2023.1007906. Hua B, Wu J, Han X, Bian X, Xu Z, Sun C, Wang R, Zhang W, Liang F, Zhang H, Li S, Li Z, Wu S.* (2023) Auxin homeostasis is maintained by sly-miR167-SlARF8A/B-SlGH3.4 feedback module in the development of locular and placenta tissues of tomato fruits. New Phytologist doi: 10.1111/nph.19391. 7. Li M, Wu S.* (2023) Root evolution: Evidence for convergent evolution of root meristem. Current Biology 33(19):R1009-R1010.8. Wu M, Chang J, Han X, Shen J, Yang L, Hu S, Huang B, Xu H, Wu S, Li P, Hua B, Yang M, Yang Z, Wu S.* (2023) A HD-Zip transcription factor specifies fates of multicellular trichomes via dosage-dependent mechanisms. Developmental Cell 58(4):278-288.e5. (Cover Story) (Highlighted by Science 2023,397(6639):1311)  9. Wu J, Sun W, Sun C, Xu C, Li S, Li P, Xu H, Zhu D, Li M, Yang L, Wei J, Hanzawa A, Tapati SJ, Uenoyama R, Miyazaki M, Rahman A*, Wu S.* (2023) Cold stress induces malformed tomato fruits by breaking the feedback loops of stem cell regulation in floral meristem. New Phytologist 237(6):2268-2283.10. Li M, Niu X, Li S, Li Q, Fu S, Wang C, Wu S.* (2023) Intercellular signaling across plasmodesmata in vegetable species. Vegetable Research. 3:22.11. Huang Y, Cui J, Li M, Yang R, Hu Y, Yu X, Chen Y, Wu Q, Yao H, Yu G, Guo J, Zhang H, Wu, S.*, Cai Y*. (2023) Conservation and divergence of flg22, pep1 and nlp20 in activation of immune response and inhibition of root development. Plant Sci. Mar 22:111686.12. Liao D, Sun C, Li S, Tauqeer A, Bian X, Shen J, Wu S.* (2023) The utilization and molecular mechanism of arbuscular mycorrhizal symbiosis in vegetables. Vegetable Research 3:1 doi: 10.48130/VR-2023-0001.13. Li M, Niu X, Li S, Fu S, Li Q, Xu M, Wang C, Wu S.*. (2023) CRISPR/Cas9 Based Cell-Type Specific Gene Knock-Out in Arabidopsis Roots. Plants (Basel). 12(12):2365.14. Liao D, Sun C, Liang H, Wang Y, Bian X, Dong C, Niu X, Yang M, Xu G*, Chen A*, Wu S.* (2022) SlSPX1-SlPHRs modulates the suppression of arbuscular mycorrhizal symbiosis by phosphate repletion in tomato. Plant Cell 34(10):4045-4065. 15. Li M, Li P, Wang C, Xu H, Wang M, Wang Y, Niu X, Xu M, Wang H, Qin Y, Tang W, Bai M, Wang W, Wu S.* (2022) Brassinosteroid signaling restricts root lignification by antagonizing SHORT-ROOT function in Arabidopsis. Plant Physiology 190(2):1182-1198.16. Xu H, Wang C, Shao G, Liu P, Wu S, Cao P, Jiang P, Wang S, Zhu H, Lin X, Tauqeer A, Lin Y, Chen W, Huang W, Wen Q, Zhong F*, Wu S.* (2022) The reference genome and full-length transcriptome of pakchoi provide insights into the cuticle formation and heat adaption. Horticulture Research 9:uhab080. 17. Xu H, Liu P, Wang C, Wu S, Lin Q, Sun W, Huang B, Xu M, Tauqeer A, Wu S.* (2022) Transcriptional Networks Regulating Suberin and Lignin Biosynthesis Link Development and ABA Response in Root Endodermis. Plant Physiology 190(2):1165-1181.18. Li M, Wang M, Lin Q, Wang M, Niu X, Cheng J, Xu M, Qin Y, Liao X, Xu J, Wu S.* (2022) Symplastic communication in root cap directs auxin distribution to modulate root development. J Integr Plant Biol. 64(4):859-870.19. Wang C, Li M, Zhao Y, Liang N, Li H, Bian X, Xu M, Yang L, Li P, Li X, Sang Y, Dong W, Wang E, Gallagher KL, Wu S.* (2021) SHORT-ROOT paralogs mediate feed-forward regulation of D-type cyclin to promote nodule formation in soybean. Proc Natl Acad Sci U S A. 119(3):e2108641119.20. Hua B, Chang J, Han X, Xu Z, Hu S, Li S, Wang R, Yang L, Yang M, Wu S, Shen J, Yu X, Wu S.* (2021) H and HL synergistically regulate jasmonate-triggered trichome formation in tomato Horticulture Research 9:uhab080.21. Chang J, Zhang F, Qin H, Liu P, Wang J, Wu S.* (2021) Mutation of SlARC6 leads to tissue-specific defects in chloroplast development in tomato. Horticulture Research 8(1):127.22. Xu M, Gu X, Yu Q, Liu Y, Bian X, Wang R, Wu, S.* (2021) Time-course observation of the reconstruction of stem cell niche in the intact root. Plant Physiology 185(4):1652-1665.23. Hua B, Chang J, Xu Z, Han X, Xu M, Yang M, Yang C, Ye Z, Wu, S.* (2021) HOMEODOMAIN PROTEIN8 Mediates Jasmonate-Triggered Trichome Elongation in Tomato New Phytologist (3):1063-1077.24. Chang J, Yang J, Wang J, Wu S.* (2021) Comprehensive observation of trichome development in Micro-tom tomato. Vegetable Research 1 (1), 1-925. Yang L, Qi S, Touqeer A, Li H, Zhang X*, Liu X*, Wu, S.* (2020) SlGT11 Controls Floral Organ Patterning and Floral Determinacy in Tomato. BMC Plant Biology 20(1):562.26. Hua, B., Chang, J., Wu, M., Xu,. Z., Zhang, F., Wu, S.* (2019) Mediation of JA signalling in glandular trichomes by the woolly/SlMYC1 regulatory module improves pest resistance in tomato. Plant Biotechnology Journal (2):375-393.27. Li P, Cai Q, Wang H, Li S, Cheng J, Li H, Yu Q, Wu, S.* (2020) Hydrogen peroxide homeostasis provides beneficial micro-environment for SHR-mediated periclinal division in Arabidopsis root. New Phytologist 228(6):1926-1938. 28. Wang C, Wang H, Li P, Li H, Xu C, Cohen H, Aharoni A, Wu, S.* (2020) Developmental programs interact with ABA to coordinate root suberization in Arabidopsis. Plant J. 104(1):241-251. 29. Wu J, Cheng J, Xu C, Qi S, Sun W, Wu, S.* (2020) AUREA maintains the balance between chlorophyll synthesis and adventitious root formation in tomato. Horticulture Research 7:166.30. Zhang L, Zhao Y, Liang H, Li X, Gallagher KL*, Wu, S.* (2020) Gateway-compatible vectors for functional analysis of proteins in cell type specific manner. Plant Methods 16:93.31. Shi P, Xie Y, Xie R, Lin Z, Yao H, Wu, S.* (2020) An Integrated Pharmacokinetic Study of an Acanthopanax senticosus Extract Preparation by Combination of Virtual Screening, Systems Pharmacology, and Multi-Component Pharmacokinetics in Rats. Front Pharmacol. 11:1295.32. Xu, M., Gu, X., Liang, N., Bian, X., Wang, H., Wu, S.* (2019) Intersected functional zone of transcriptional regulators patterns stemness within stem cell niche of root apical meristem. Journal of Integrative Plant Biology doi: 10.1111/jipb.12881.33. Chang, J., Xu, Z., Li, M., Yang, M., Qin, H., Yang, J., Wu, S.* (2019) Spatiotemporal cytoskeleton organizations determine morphogenesis of multicellular trichomes in tomato. PLoS Genet. 15(10):e1008438.34. Li, P., Yu, Q., Gu, X., Xu, C., Qi, S., Wang, H., Zhong, F., Baskin, T.B., Rahman, A., Wu, S.* (2018) Construction of a Functional Casparian Strip in Non-endodermal Lineages Is Orchestrated by Two Parallel Signaling Systems in Arabidopsis thaliana. Current Biology 28(17):2777-2786.35. Xu, M., Qi, S., Chen, F., Zhang, L., Wu, S.* (2018) Loss or duplication of key regulatory genes coincides with environmental adaptation of stomatal complex in Nymphaea colorata and Kalanchoe laxiflora. Horticulture Research 5:42. doi: 10.1038/s41438-018-0048-8.36. Li, P., Yang, M., Chang, J., Wu, J., Zhong, F., Rahman, A., Qin, H. and Wu, S.* (2018) Spatial Expression and Functional Analysis of Casparian Strip Regulatory Genes in Endodermis Reveals the Conserved Mechanism in Tomato. Front. Plant Sci. 9:832. doi: 10.3389/fpls.2018.0083237. Zhong, F., Wang, S., Roan, S., Lin, B., Chen, I., Lin, Y., Pang, J., Wu, S.* (2018) Characterization of nitrate assimilation in Lactuca sativa L. under different nitrogen sources. Plant Growth Regulation 86 (1), 1-10.38. Zhong F, Zhou X, Lin Y, Chen X, Xu R, Wang S, Lin Y, Pang J, Wu, S.* (2018) Sepal morphology affects flower and fruit development in Luffa cylindrica. Fresenius Environmental Bulletin 27 (6), 4006-401339. Yu Q, Li P, Liang N, Wang H, Xu M, Wu, S. *（2017）Specifying cell fate in roots requires coordinative lineage instruction and positional reprogramming. Plant Physiol. 175(2):816-827.40. Liu, Y., Xu, M., Liang, N., Zheng, Y., Yu, Q., Wu, S. * (2017) Symplastic communication spatially directs local auxin biosynthesis to maintain root stem cell niche in Arabidopsis, Proc Natl Acad Sci U S A. 114(15):4005-4010. 41. Yang, B., Zhou, X., Xu, R., Wang, J., Lin, Y., Pang, J., Wu, S. *, Zhong, F. * (2016)  Comprehensive Analysis of Photosynthetic Characteristics and Quality Improvement of Purple Cabbage under Different Combinations of Monochromatic Light, Front Plant Sci. 29;7:1788. 42. Wu, S.*, O'Lexy, R., Xu, M., Sang, Y., Chen, X., Yu, Q. & Gallagher, K.* (2016) A Symplastic signaling instructs cell division, cell expansion, and cell polarity in the ground tissue of Arabidopsis thaliana roots, Proc Natl Acad Sci U S A. 113(41):11621-11626. 43. Wu, S., Hayashi, T., Lee, C.M., Price, S., Divol, F., Henry, S., Pauluzzi, G., Perin, C. & Gallagher, K. (2014) A plausible mechanism, based upon SHORT-ROOT movement, for regulating the number of cortex cell layers in roots, Proc Natl Acad Sci U S A. 111(45):16184-9. 44. Wu, S. & Gallagher, K.L. (2014) The movement of the non-cell-autonomous transcription factor, SHORT-ROOT relies on the endomembrane system, Plant J. 80(3):396-409. 45. Wu, S. & Gallagher, K.L. (2015) Techniques for Assessing the Effects of Pharmacological Inhibitors on Intercellular Protein Movement.  Methods in Molecular Biology. 1217:245-58.46. Wu, S. & Gallagher, K.L. (2013) Intact microtubules are required for the intercellular movement of the SHORT-ROOT transcription factor. Plant J. 74(1):148-159.  47. Wu, S., Baskin, T.I. & Gallagher, K.L. (2012) Mechanical fixation techniques for processing and orienting delicate samples, such as the root of Arabidopsis thaliana, for light or electron microscopy. Nature Protocols. 7(6):1113-24. 48. Wu, S. & Gallagher, K.L. (2012) Transcription Factors on the Move. Curr Opin Plant Biol. 15(6):645-651. 49. Koizumi, K.*, Wu, S.*, MacRae-Crerar, A., Gallagher, K.L. (2011) An essential protein that interacts with endosomes and promotes movement of the SHORT-ROOT transcription factor. Current Biology. 21(18):1559-1564. 50. Wu, S. & Gallagher, K.L. (2011) Mobile protein signals in plant development. Curr Opin Plant Biol. 14(5):563-70 51. Wu, S.*, Koizumi, K.*, Macrae-Crerar, A., Gallagher, K.L. (2011) Assessing the utility of photoswitchable fluorescent proteins for tracking intercellular protein movement in the Arabidopsis root. PLoS One. 2011; 6(11):e27536. 52. Wu, S., Scheible, W. R., Schindelasch, D., Van Den Daele H., De Veylder L., & Baskin, T. I. (2010) A conditional mutation in Arabidopsis thaliana separase induces chromosome non-disjunction, aberrant morphogenesis and cyclin B1;1 stability. Development. 137(6):953-961. 53. Li Y, Luo J, Han X, Chen R, Zhou Y, Yu H, Chu Z, Lu Y, Gu X, Wu S, Wang P, Kuang H, Ouyang B. (2023) Folate shapes plant root architecture by affecting auxin distribution. Plant J doi: 10.1111/tpj.16093.54. Xu Z, Qu X, Wu S., Wang P*. (2023) Studying the Organization of the Actin Cytoskeleton in the Multicellular Trichomes of Tomato. Methods Mol Biol. 2604:327-335.55. Zhao J, Bo K, Pan Y, Li Y, Yu D, Li C, Chang J, Wu S., Wang Z, Zhang X, Gu X, Weng Y*. (2023) Phytochrome-interacting factor PIF3 integrates phytochrome B and UV-B signaling pathways to regulate gibberellin- and auxin-dependent growth in cucumber hypocotyls. J Exp Bot. 74(15):4520-4539.56. Tian Y, Zhao N, Wang M, Zhou W, Guo J, Han C, Zhou C, Wang W, Wu S, Tang W, Fan M, Bai MY*. (2022) Integrated regulation of periclinal cell division by transcriptional module of BZR1-SHR in Arabidopsis roots. New Phytol., 233(2):795-808.57. Yang L, Zhu M, Yang Y, Wang K, Che Y, Yang S, Wang J, Yu X, Li L, Wu S, Palme K, Li X.  (2022) CDC48B facilitates the intercellular trafficking of SHORT-ROOT during radial patterning in roots. J Integr Plant Biol. 64(4):843-858.58. Wang Z, Rong D, Chen D, Xiao Y, Liu R, Wu S, Yamamuro C. (2021) Salicylic acid promotes quiescent center cell division through ROS accumulation and down-regulation of PLT1, PLT2, and WOX5. J Integr Plant Biol. 63(3):583-596.59. Bai Y, Shen Y, Zhang Z, Jia Q, Xu M, Zhang T, Fang H, Yu X, Li L, Liu D, Qi X, Chen Z, Wu S, Zhang Q, Liang C. (2021) A GPAT1 Mutation in Arabidopsis Enhances Plant Height but Impairs Seed Oil Biosynthesis. Int J Mol Sci. 22(2):785.60. Dong W, Zhu Y, Chang H, Wang C, Yang J, Shi J, Gao J, Yang W, Lan L, Wang Y, Zhang X, Dai H, Miao Y, Xu L, He Z, Song C, Wu S, Wang D, Yu N, Wang E. (2020) An SHR-SCR module specifies legume cortical cell fate to enable nodulation. Nature 589(7843):586-590.61. Cohen H, Fedyuk V, Wang C, Wu S, Aharoni A. (2020) SUBERMAN regulates developmental suberization of the Arabidopsis root endodermis. Plant J. doi: 10.1111/tpj.14711.62. Wu ML, Cui YC, Ge L, Cui LP, Xu ZC, Zhang HY, Wang ZJ, Zhou D, Wu S, Chen L, Cui H. (2020) NbCycB2 represses Nbwo activity via a negative feedback loop in tobacco trichome development. J Exp Bot. doi: 10.1093/jxb/erz542.63. Spiegelman, Z., Wu, S., Gallagher, K.L. (2019) A role for the endoplasmic reticulum in the cell-to-cell movement of SHORT-ROOT. Protoplasma. 256(5):1455-1459.64. Qi SL, Lin QF, Feng XJ, Han HL, Liu J, Zhang L, Wu S, Le J, Blumwald E, Hua X.(2019) IDD16 negatively regulates stomatal initiation via trans-repression of SPCH in Arabidopsis. Plant Biotechnol J. doi: 10.1111/pbi.13070.65. Henry S, Dievart A, Divol F, Pauluzzi G, Meynard D, Swarup R, Wu S., Gallagher KL, Perin C. * (2017) SHR overexpression induces the formation of supernumerary cell layers with cortex cell identity in rice. Developmental biology 425 (1), 1-766. Chen, X., Wu, S., Liu, Z., Friml, J. (2016) Environmental and Endogenous Control of Cortical Microtubule Orientation. Trends Cell Biol. 26(6):409-19.67. Koizumi, K., Hayashi, T., Wu, S., Gallagher, K.L. (2012) The SHORT-ROOT protein acts as a mobile, dose-dependent signal in patterning the ground tissue. Proc Natl Acad Sci U S A. 109(32):13010-5. (Faculty of 1000)68. Sang, Y., Silva-Ortega, C.O., Wu, S., Yamaguchi, N., Wu, M.F., Pfluger, J., Gillmor, S., Gallagher, K.L., Wagner, D. (2012) Mutations in two non-canonical Arabidopsis SWI2/SNF2 chromatin remodeling ATPases cause embryogenesis and stem cell maintenance defects. Plant J. 72(6): 1000-1014. 69. Vatén, A., Dettmer, J., Wu, S., Stierhof, Y.D., Miyashima, S., Yadav, S.R., Roberts, C.J., Campilho, A., Bulone, V., Lichtenberger, R., Lehesranta, S., Mähönen, A.P., Kim, J.Y., Jokitalo, E., Sauer, N., Scheres, B., Nakajima, K., Carlsbecker, A., Gallagher, K.L., Helariutta, Y. (2011) Callose biosynthesis regulates symplastic trafficking during root development. Developmental Cell. 21(6):1144-1155. 70. Yang, X., Boateng, K.A., Yuan, L., Wu, S., Baskin, T.I., Makaroff, C.A. (2011) The radially swollen 4 separase mutation of Arabidopsis thaliana blocks chromosome disjunction and disrupts the radial microtubule system in meiocytes. PLoS One. 29;6(4):e19459. 71. Rahman, A., Takahashi, M,, Shibasaki, K., Wu, S., Inaba T., Tsurumi, S. & Baskin, T. I. (2010) Gravitropism of Arabidopsis thaliana roots requires the polarization of PIN2 toward the root tip in meristematic cortical cells. Plant Cell. 22(6):1762-76 72. Bischoff, V., Cookson, S. J., Wu, S. & Scheible, W. R. (2009) Thaxtomin A affects CESA-complex density, expression of cell wall genes, cell wall composition, and causes ectopic lignification in Arabidopsis thaliana seedlings. J. Exp. Bot. 60(3): 955-65.